Synthetic Lethality in Cancer Therapeutics
نویسندگان
چکیده
منابع مشابه
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Synthetic lethality is based on the incompatibility of cell survival with the loss of function of two or more genes, not with loss of function of a single gene. If targets of synthetic lethality are deregulated or mutated in cancer cells, the strategy of synthetic lethality can result in significant increase of therapeutic efficacy and a favourable therapeutic window. In this review, we discuss...
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ژورنال
عنوان ژورنال: Annual Review of Cancer Biology
سال: 2017
ISSN: 2472-3428
DOI: 10.1146/annurev-cancerbio-042016-073434